Product Name: 1,2-Naphthoquinone
Synonyms: Ortho-naphthoquinone, 1,2-Naphthalenediol
Chemical Formula: C10H6O2
CAS Number: 524-42-5
Recommended Use: Laboratory chemicals, research, dye intermediates
Manufacturer: Refer to label or purchase source
Emergency Contact: Refer to local regulations or supplier guidance for immediate assistance
Classification: Acute toxicity (oral, dermal), Skin irritation, Eye damage, Respiratory hazards
GHS Label Elements: Signal Word: Danger; Hazard statements: Toxic if swallowed, in contact with skin or inhaled, causes skin irritation, serious eye damage
Symptoms of Exposure: Burning sensation in eyes or skin, respiratory discomfort, headache, nausea
Precautionary Statements: Avoid breathing dust or vapors, wash thoroughly after handling, store in a well-ventilated space, wear eye, skin, and respiratory protection
Chemical Name: 1,2-Naphthoquinone
Concentration: ≥98% w/w
Impurities: May contain trace amounts of 1,4-naphthoquinone as contaminant, organic solvents from synthesis steps
Molecular Weight: 158.16 g/mol
Inhalation: Remove to fresh air, seek medical attention for persistent symptoms, provide oxygen if breathing is difficult
Skin Contact: Wash thoroughly with soap and water for at least 15 minutes, remove contaminated clothing, seek medical care for persistent irritation
Eye Contact: Rinse cautiously with running water for several minutes, lift eyelids, obtain medical advice promptly for pain or visual changes
Ingestion: Rinse mouth with water if person is conscious, do not induce vomiting, seek urgent medical attention
Most Important Symptoms: Severe eye damage, respiratory inflammation, gastrointestinal discomfort
Notes for Physicians: Treat symptomatically, monitor for delayed effects
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray (cooling only, avoid direct stream)
Special Hazards: May release irritating or toxic fumes like carbon monoxide and carbon dioxide during combustion
Protective Equipment: Firefighters require self-contained breathing apparatus, full protective gear
Special Procedures: Keep containers cool with water spray, isolate fire scene, avoid heavy run-off into drains
Unusual Hazards: Dust may form explosive mixtures with air in enclosed spaces
Personal Precautions: Wear adequate protective clothing, gloves, safety goggles, and respiratory equipment
Environmental Precautions: Prevent entry to sewers, surface, or groundwater
Methods for Containment: Isolate spill area, contain dust by moistening with water spray
Cleanup Methods: Sweep up material carefully, place it into closed labeled containers for disposal, ventilate area, clean with damp cloth to remove residues, avoid raising dust
Decontamination: Dispose contaminated materials according to local regulations
Handling: Use in chemical fume hood, avoid skin and eye contact, avoid dust formation, wear protective gear
Storage: Keep tightly closed in original container, store in a cool, dry, and well-ventilated area, protect from light, separate from food, incompatible chemicals like strong reducing agents, acids, and bases
Specific Uses: Only for laboratory, industrial, or research applications, keep away from children or unauthorized persons
Exposure Limits: No established OSHA, NIOSH, or ACGIH thresholds, minimize exposure as a best practice
Engineering Controls: Use local exhaust ventilation, chemical fume hood, closed systems for transfer, keep eye wash station and safety shower nearby
Personal Protective Equipment: Safety glasses or face shield, chemical-resistant gloves (nitrile, neoprene), laboratory coat or apron, dust mask or NIOSH-approved respirator for dusty environments
Hygiene Requirements: Wash hands thoroughly after handling, remove contaminated clothing immediately, do not eat or drink near material
Appearance: Yellow to orange crystalline powder
Odor: Characteristic, slightly pungent
Odor Threshold: Not available
pH: Not applicable (solid material)
Melting Point: 126–130°C (259–266°F)
Boiling Point: Decomposes before boiling
Flash Point: Not established
Evaporation Rate: Not relevant (non-volatile solid)
Flammability: Not easily flammable, dust may cause explosion in confined spaces
Vapor Pressure: Not significant at room temperature
Vapor Density: Not available
Density: ~1.47 g/cm³
Solubility: Slightly soluble in cold water, more soluble in ethanol, ether, and acetone
Partition Coefficient (log Kow): Estimated 1.79
Auto-ignition Temperature: Not available
Decomposition Temperature: >150°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended conditions of use and storage
Reactive Hazards: Can react with strong reducing agents, strong bases, acids, and oxidizers
Decomposition Products: Carbon monoxide, carbon dioxide, organic fumes
Conditions to Avoid: High temperatures, contact with incompatible substances, intense light
Polymerization: Does not undergo hazardous polymerization
Acute Toxicity: Harmful if swallowed, inhaled, or absorbed through the skin; LD50 (oral, rat) reported at approximately 100 mg/kg
Possible Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Irritation: Causes skin and eye burns
Sensitization: Not a confirmed sensitizer, but repeated contact could cause allergic reactions
Chronic Effects: Can damage respiratory system, cause dermatitis by prolonged or frequent exposure
Carcinogenicity: No clear evidence; not classified by IARC, OSHA, or NTP
Reproductive Effects: Not thoroughly studied
Mutagenicity: Some published studies indicate possible genotoxicity in laboratory settings
Medical Conditions Aggravated by Exposure: Pre-existing skin, eye, or respiratory conditions may worsen
Environmental Toxicity: Harmful to aquatic life, can cause long lasting effects
Mobility in Soil: Potential to leach into soil and water bodies if not contained
Persistence and Degradability: Degradation expected to be slow under environmental conditions
Bioaccumulation: Potential for bioaccumulation exists based on octanol-water partitioning
Additional Information: Prevent large quantities from entering waterways, toxic to fish and micro-organisms, local regulations may apply for environmental releases
Disposal Methods: Collect waste in closed, properly labeled containers
Contaminated Packaging: Dispose as hazardous waste following local, national, and international requirements
Recycling or Recovery: Not appropriate due to toxicity and hazardous nature
Additional Disposal Guidance: Incinerate waste at licensed facility, never pour into drains, avoid uncontrolled landfill waste
UN Number: Not specifically assigned—check with regulatory authorities
Transport Hazard Class: Not regulated as a dangerous good in small quantities, but treat as hazardous
Packing Group: III (if applicable under national rules)
Labels: Toxic Substances, Irritant, Environmental Hazard (if required)
Special Transport Precautions: Protect from physical damage during transit, transport in closed, clearly labeled containers
Regulatory Bodies: Refer to DOT, IATA, IMDG for specific packaging or handling instructions
OSHA Status: Not specifically listed, general hazardous chemical requirements apply
TSCA Status: Listed in TSCA Inventory for research and industrial use
REACH Status: Subject to registration requirements in the EU
SARA Title III: Not covered under SARA 302, 304, or 313 specific threshold limits
California Prop 65: Not listed as a Proposition 65 chemical
WHMIS Classification (Canada): D2B (Toxic material causing other toxic effects)
Other International Regulations: Consult with national chemical safety boards for local restrictions or guidelines
